SENTIS™ – Hereditary Breast and Ovarian Cancer Panel

SENTIS™ – Hereditary Breast and Ovarian Cancer Panel

Introduction

BGI’s hereditary risk screening cancer panels target genes previously linked to a predisposition of cancer. Panel selection was based on expert curation of scientific literature and other high quality resources, including formal medical guidelines.

BGI’s Hereditary Breast and Ovarian (HBOC) panel provides health providers and patients with information on 21 genes associated with Hereditary Breast and Ovarian Cancer (HBOC) based on recent scientific and clinical literature. BGI detects different alterations including germline SNV, Indels and CNV.

 

  • SUITABLE FOR:

    Patients suspected of being at increased risk of HBOC

  • TA TIME:

    20 working days

  • SAMPLE:

    Peripheral blood, DNA, Saliva

  • TECHNOLOGY:

    Target region capture, high-throughput sequencing

Panels and Genes

Test list

Gene list

Sentis BRCA (2 genes) panel

BRCA1, BRCA2

Sentis Hereditary Breast and Ovarian (21 genes) panel

BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1,NBN, MRE11A,MSH2, MSH6, MUTYH, PMS1,PMS2, RAD50, RAD51C

Why Choose the BGI SENTIS™ - Hereditary Breast and Ovarian Cancer Panel?

  • Comprehensive – whole exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications, rearrangements
  • Robust – clinically important (pathogenic or likely pathogenic) variants are verified by Sanger Sequencing while large gene rearrangements are verified by qPCR
  • Convenient – test from blood or saliva; DNA is also accepted
  • Professional – state-of-the-art variant database ensures up-to-date analysis and interpretation. BGI also have a dedicated genetic counselling team offering professional genetic counselling services via email

Workflow

  • STEP 1

    Counselling and consent

  • STEP 2

    Sample collection

  • STEP 3

    Sample shipped to BGI and analyzed

  • STEP 4

    Report and Genetic counselling

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