Human cancers typically carry several types of genomic variations, such as Single Nucleotide Variants (SNV), Copy Number Variations (CNV), Insertions and Deletions (InDels), Structural Variants (SV), and Gene Fusions. These genetic alterations infer important insights for the discovery and development of biomarkers and for use in basic cancer research, patient stratification and clinical research.
BGI has developed multiple comprehensive and specific cancer panels based on many years of cancer research experience and proprietary database generation. These NGS panels are all capture-based, designed to detect all types of genomic tumor alterations, including base substitutions, insertions and deletions, copy number alterations, and selected gene fusions.
For example, our most comprehensive OseqTM Solid Cancer Panel includes 1,053 genes that are strongly supported as clinically actionable cancer genes, with high frequency alterations in the COSMIC database, or play key roles in core cancer pathways.
OseqTM Solid Tumor Panels
Multiple OseqTM panels are available for solid tumor research. The OseqTM T for tissue biopsy and OseqTM ctDNA, and OseqTM lung panels are approved clinical test in China. All the panels are for Research use only outside of China.
OseqTM panels are designed for the identification of clinically actionable mutations, as well as discovery of novel variants with important functions, including, but not limited to Lung Cancer, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Melanoma, and Lymphoma.
Why OseqTM Solid Cancer Panels
Solid Cancer Panel Applications
Drug target discovery
Understanding of drug response
Understanding of drug resistance
Under a 21CFR Part 11 compliant LIMS system, your samples are tracked from sample accessioning through data reporting. Highly experienced laboratory professionals follow strict quality procedures to ensure the integrity of the results.
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Sequencing Service Specification
BGI solid cancer panel sequencing services are executed with the Illu HiSeq sequencing system, in our CAP and CLIA certified service laboratory in Hong Kong. For samples from China, we offer services from Chinese clinical laboratories in mainland China, with our cFDA cleared BGISEQ-500 sequencing platform.
Sample Preparation and Services
100bp and 150bp paired-end sequencing options available
NimbleGen SeqCap or KAPA Hyper Prep kit for library construction and enrichment
Raw data and bioinformatics analysis are available in standard file formats
Advanced and custom bioinformatics data analysis available
Cloud-based data storage and delivery system
Sequencing Quality Standard
Guaranteed ≥ 80% of bases with quality score of ≥ Q30
Standard sequencing coverage ≥ 400X is recommended for cancer samples
Turn Around Time
Typical 30 working days from sample QC acceptance to filtered raw data availability for research.
Expedited services are available, including 10-day service for prospective studies. Contact your local BGI specialist for details.
Raw data and bioinformatics analysis are delivered in standard file formats.
Oseq Data Analysis
SNP calling and annotation
SNP validation and comparison
SNP functionality and conservation prediction
InDel calling and annotation
CNV calling and annotation
Gene fusion calling and annotation
We can process your gDNA, Blood, Cell line, Fresh frozen tissue, FFPE samples with the following general requirements: