We have developed innovative solutions for optimizing the processes of PTM identification of purified protein, modified protein profiling, and protein PTM quantification in complex biological matrices and other complex mixtures.
Post-translational modification (PTM) of proteins refers to the chemical changes proteins may undergo after translation. Common PTMs include Phosphorylation, Glycosylation, Acetylation and Ubiquitination. As a result, identifying and understanding PTMs is key for the study of cell biology and the treatment and prevention of disease.
BGI has extensive experience in the field of PTM Proteomics1,2 and has developed reliable workflows using market leading technologies and a bioinformatics infrastructure that is second to none.
Modified peptides enrichment
 Zhang, Y., et al., Evidence for Differential Glycosylation of Trophoblast Cell Types. Mol Cell Proteomics, 2016 Jun;15(6):1857-66. doi: 10.1074/mcp.M115.055798.
 Hao P L, et al., Correction of Errors in Tandem Mass Spectrum Extraction Enhances Phosphopeptide Identification. J. Proteome Res., 2013, 12, 12, 5548–5557. doi: 10.1021/pr4004486.