Publications

BGI has generated over 2097 publications in top-tier journals, such as Nature and Science. The list below is a selection from the total publications. (All links lead to external websites.)

2018

Metagenomics

BGISEQ-500

Animal

A gene catalogue of the Sprague-Dawley rat gut metagenome

2018

BGISEQ-500

Plant

A guide to sequence your favorite plant genomes

2018

Metagenomics

BGISEQ-500

Human

A novel affordable reagent for room temperature storage and transport of fecal samples for metagenomic analyses

2018

RNA-Seq

BGISEQ-500

Plant

A novel HD-ZIP IV/MIXTA complex promotes glandular trichome initiation and cuticle development in Artemisia annua

2017

WGS

BGISEQ-500

Human

A reference human genome dataset of the BGISEQ-500 sequencer

2018

Exome

BGISEQ-500

Human

A novel PTCH1 mutation underlies non‐syndromic cleft lip and/or palate in a Han Chinese family

2018

Exome

BGISEQ-500

Human

A novel mutation in PRPF31, causative of autosomal dominant retinitis pigmentosa, using the BGISEQ-500 sequencer

2018

RNA-Seq

BGISEQ-500

Human

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells

2018

RNA-Seq

BGISEQ-500

Animal

A small set of differentially expressed genes was associated with two color morphs in natural populations of the pea aphid Acyrthosiphon pisum

2018

RNA-Seq

BGISEQ-500

Human

An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation

2018

RNA-Seq

BGISEQ-500

Human

Anti‑fbrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn’s Disease

2017

Metagenomics

BGISEQ-500

Human

Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing

2017

RNA-Seq

BGISEQ-500

Plant

AtACS8 plays a critical role in the early biosynthesis of ethylene elicited by copper ions in Arabidopsis

2018

RNA-Seq

BGISEQ-500

Human

Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival

2018

RNA-Seq

BGISEQ-500

Animal

Cambogin suppresses dextran sulphate sodium‐induced colitis by enhancing Treg cell stability and function

2017

RNA-Seq

BGISEQ-500

Animal

Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia

2018

Small RNA

BGISEQ-500

Microorganism

Comparative genome-wide analysis of extracellular small RNAs from the mucormycosis pathogen Rhizopus delemar

2016

RNA-Seq

BGISEQ-500

Animal

Comparative transcriptome analysis of chemosensory genes in two sister leaf beetles provides insights into chemosensory speciation.

2018

RNA-Seq

BGISEQ-500

Plant

Comparative transcriptome analysis reveals key genes potentially related to soluble sugar and organic acid accumulation in watermelon

2018

Plastome DNA

BGISEQ-500

Plant

Complete plastome sequence of Dracaena cambodiana (Asparagaceae): a species considered “Vulnerable” in Southeast Asia

2018

RNA-Seq

BGISEQ-500

Animal

Cranial Irradiation Induces Hypothalamic Injury and Late-Onset Metabolic Disturbances in Juvenile Female Rats

2016

Small RNA

BGISEQ-500

Human

cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs

2017

RNA-Seq

BGISEQ-500

Animal

Data Descriptor: RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation

2018

RNA-Seq

BGISEQ-500

Microorganism

Differential gene expression in Escherichia coli during aerosolization from liquid suspension

2017

RNA-Seq

BGISEQ-500

Animal

Differential gene expression in the intestine of sea cucumber (Apostichopus japonicus) under low and high salinity conditions

2018

Small RNA

BGISEQ-500

Plant

DDM1 represses noncoding RNA expression and RNA-directed DNA methylation in heterochromatin

2017

RNA-Seq

BGISEQ-500

Human

Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells

2017

RNA-Seq

BGISEQ-500

Plant

Draft genome sequence of the Tibetan medicinal herb, Rhodiola crenulata

2017

RNA-Seq

BGISEQ-500

Animal

Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila

2018

RNA-Seq

BGISEQ-500

Animal

Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

2017

RNA-Seq

BGISEQ-500

Human

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner

2017

RNA-Seq

BGISEQ-500

Animal

Effects of In Utero PFOS Exposure on Transcriptome, Lipidome and Function of Mouse Testis

2018

Metagenomics

BGISEQ-500

Human

Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis: protocol for a 6-month, double-blind, randomised, placebo-controlled trial

2017

RNA-Seq

BGISEQ-500

Human

Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

2017

RNA-Seq

BGISEQ-500

Animal

Exploring gene expression changes in the amphioxus gill after poly(I:C) challenge using digital expression profiling

2018

RNA-Seq

BGISEQ-500

Plant

Expression of grape ACS1 in tomato decreases ethylene and alters the balance between auxin and ethylene during shoot and root formation

2018

RNA-Seq

BGISEQ-500

Human

FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway

2017

RNA-Seq

BGISEQ-500

Human

FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt/β-catenin Signaling Pathway

2017

RNA-Seq

BGISEQ-500

Plant

Gene expression profiling of ramie roots during hydroponic induction and adaption to aquatic environment

2018

RNA-Seq

BGISEQ-500

Animal

Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells

2017

RNA-Seq

BGISEQ-500

Animal

Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions

2018

RNA-Seq

BGISEQ-500

Animal

Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression

2017

RNA-Seq

BGISEQ-500

Human

Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia

2017

RNA-Seq

BGISEQ-500

Human

High expression of diffuse panbronchiolitis critical region 1 gene promotes cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma

2018

RNA-Seq

BGISEQ-500

Plant

Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor

2018

RNA-Seq

BGISEQ-500

Microorganism

Identification and Characterization of als Genes Involved in D-Allose Metabolism in Lineage II Strain of Listeria monocytogenes

2018

Exome

BGISEQ-500

Human

Identification of a mutL‑homolog 1 mutation via whole‑exome sequencing in a Chinese family with Gardner syndrome

2017

RNA-Seq

BGISEQ-500

Microorganism

Identification of differentially expressed genes involved in spore germination of Penicillium expansum by comparative transcriptome and proteome approaches

2018

Metagenomics

BGISEQ-500

Human

Identification of pathogens in culture-negative infective endocarditis with metagenomic analysis

2018

RNA-Seq

BGISEQ-500

Microorganism

In Situ Lignin Bioconversion Promotes Complete Carbohydrate Conversion of Rice Straw by Cupriavidus basilensis B-8

2018

RNA-Seq

BGISEQ-500

Animal

KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

2018

RNA-Seq

BGISEQ-500

Human

Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery

2017

RNA-Seq

BGISEQ-500

Human

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

2017

RNA-Seq & ChIP-Seq

BGISEQ-500

Animal

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

2017

RNA-Seq

BGISEQ-500

Animal

Orally Administrated Baker’s Yeast beta-Glucan Promotes Glucose and Lipid Homeostasis in the Livers of ob/ob Mice

2018

RNA-Seq

BGISEQ-500

Human

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through
repression of phosphoglycerate dehydrogenase

2017

RNA-Seq

BGISEQ-500

Plant

Overexpression of OsHSP18.0-CI Enhances Resistance to Bacterial Leaf Streak in Rice

2017

RNA-Seq

BGISEQ-500

Human

Overexpression of placenta specific 8 is associated with malignant progression and poor prognosis of clear cell renal cell carcinoma

2018

RNA-Seq

BGISEQ-500

Plant

Overexpression of VaWRKY14 increases drought tolerance in Arabidopsis by modulating the expression of stress-related genes

2018

RNA-Seq

BGISEQ-500

Animal

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

2017

RNA-Seq

BGISEQ-500

Human

PBRM1 restricts the basal activity of innate immune system through repressing RIG-I-like receptor signaling and is a potential prognostic biomarker for colon cancer

2018

RNA-Seq

BGISEQ-500

Plant

Phytochrome A Negatively Regulates the Shade Avoidance Response by Increasing Auxin/Indole Acidic Acid Protein Stability

2018

RNA-Seq

BGISEQ-500

Animal

Preinduction with bone morphogenetic protein-2 enhances cardiomyogenic differentiation of c-kit+ mesenchymal stem cells and repair of infarcted myocardium

2017

RNA-Seq

BGISEQ-500

Human

Probing impaired neurogenesis in human brain organoids exposed to alcohol

2018

BGISEQ-500

Human

Quality Control of Next-generation Sequencing-based In vitro Diagnostic Test for Onco-relevant Mutations Using Multiplex Reference Materials in Plasma

2017

RNA-Seq

BGISEQ-500

Human

Recessive mutation in EXOSC3 associates with mitochondrial dysfunction and pontocerebellar hypoplasia

2018

Methodology-index

BGISEQ-500

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

2018

RNA-Seq

BGISEQ-500

Animal

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

2018

Transcriptome resequencing

BGISEQ-500

Microorganism

RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant

2018

RNA-Seq

BGISEQ-500

Human

Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing

2018

RNA-Seq

BGISEQ-500

Human

Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis

2018

RNA-Seq

BGISEQ-500

Human

Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells

2018

Methodology-long fragment

BGISEQ-500

Single tube bead-based DNA co-barcoding for cost effective and accurate sequencing, haplotyping, and assembly

2018

RNA-seq(Q)

BGISEQ-500

Human

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

2018

RNA-Seq

BGISEQ-500

Human

Small molecules capable of activating DNA methylation–repressed genes targeted by the p38 mitogen-activated protein kinase pathway

2018

RNA-Seq

BGISEQ-500

Human

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

2018

RNA-Seq

BGISEQ-500

Human

TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression

2017

RNA-Seq

BGISEQ-500

Animal

Systemic response of the stony coral Pocillopora damicornis against acute cadmium stress

2018

Transcriptome de novo

BGISEQ-500

Plant

The biosynthetic origin of psychoactive kavalactones in kava

2018

RNA-Seq

BGISEQ-500

Microorganism

The Catabolite Repressor/Activator Cra Is a Bridge Connecting Carbon Metabolism and Host Colonization in the Plant Drought Resistance-Promoting Bacterium Pantoea alhagi LTYR-11Z

2017

Epigenomics

BGISEQ-500

Human

The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.

2018

RNA-Seq

BGISEQ-500

Plant

The GARP/MYB-related grape transcription factor AQUILO improves cold tolerance and promotes the accumulation of raffinose family oligosaccharides

2018

RNA-Seq

BGISEQ-500

Animal

The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking

2018

RNA-Seq

BGISEQ-500

Human

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1

2018

RNA-Seq

BGISEQ-500

Animal

The Molecular Mechanism Underlying Pro-apoptotic Role of Hemocytes Specific Transcriptional Factor Lhx9 in Crassostrea hongkongensis

2018

RNA-Seq

BGISEQ-500

Animal

Transcriptome profiling of immune-responsive genes in the intestine of Cynoglossus semilaevis Günther challenged with Shewanella algae

2018

Transcriptome de novo

BGISEQ-500

Animal

Transcriptome profiling reveals differential gene expression of detoxification enzymes in Sitophilus zeamais responding to terpinen-4-ol fumigation

2018

Transcriptome resequencing

BGISEQ-500

Plant

Transcriptome resequencing analysis of the responses of Ty5-Mediated
resistance to TYLCV via in resistant vs.
susceptible tomato cultivars

2017

RNA-Seq

BGISEQ-500

Plant

Transcriptome sequencing and comparative analysis of differentially-expressed isoforms in the roots of Halogeton glomeratus under salt stress

2017

Small RNA

BGISEQ-500

Animal

Transcriptome-wide analysis of immune-responsive microRNAs against poly (I:C) challenge in Branchiostoma belcheri by deep sequencing and bioinformatics

2017

RNA-Seq

BGISEQ-500

Animal

Transcriptomic analysis reveals transgenerational effect of hypoxia on the neural control of testicular functions

2017

RNA-Seq

BGISEQ-500

Animal

Using Next-Generation Sequencing to Detect Differential Expression Genes in Bradysia odoriphaga after Exposure to Insecticides

2018

RNA-Seq

BGISEQ-500

Human

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy

2017

WGS

BGISEQ-500

Animal

Comparative performance of the BGISEQ-500 versus Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing

2018

RNA-seq & miRNA

BGISEQ-500

Human

Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy

2018

RNA-Seq

BGISEQ-500

Plant

Arabidopsis thaliana ACS8 plays a crucial role in the early biosynthesis of ethylene elicited by Cu2+ ions

2018

Transcriptome de novo

BGISEQ-500

Animal

Comparative transcriptome analysis of Sogatella furcifera (Horváth) exposed to different insecticides

2018

RNA-Seq

BGISEQ-500

Plant

Compositional and transcriptomic analysis associated with cuticle lipid production on rosette and inflorescence stem leaves in the extremophyte Thellungiella salsuginea

2017

RNA-Seq

BGISEQ-500

Microorganism

Coordination of metabolic pathways: Enhanced carbon conservation in 1,3-propanediol production by coupling with optically pure lactate biosynthesis

2017

RNA-Seq

BGISEQ-500

Plant

Genome-scale mRNA transcriptomic insights into the responses of oilseed rape (Brassica napus L.) to varying boron availabilities

2018

WGS

BGISEQ-500

Human

Germline and somatic variant identification using BGISEQ-500 and HiSeq X Ten whole genome sequencing

2018

Yeast DNA

BGISEQ-500

Microorganism

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods

Quick Contact