Sample Preparation and Services
- PCR and PCR-free library methods are available
- 100bp or 150bp Paired end sequencing
- Choice of sequencing depth: low pass WGS (1x, 4x, or custom)
- CAP/CLIA laboratory services available
Low-pass Whole Genome Sequencing (WGS) provides an accurate and cost-effective solution to measuring genome-wide genetic variation. Low-pass WGS is an increasingly-popular high-throughput tool for large-scale genomics projects that traditionally have used legacy technology like genotyping arrays. NGS technology outperforms genotyping arrays by providing an order of magnitude more data, greater statistical power, and enhanced variant discovery capabilities.
Applications include genome-wide association studies, biobank profiling, and pharmacogenomics. In addition, low-pass WGS can be used to build custom reference panels to improve imputation of future samples from a specific population or disease group.
DNBSEQ™ Sequencing and Gencove Imputation
The unique combination of BGI DNBSEQ™ sequencing and Gencove’s ImputeSeq low-pass imputation pipeline enables researchers to efficiently obtain fully-imputed, analysis-ready VCF files from DNA in a single service.
BGI Low-Pass Whole Genome Sequencing services are executed with the DNBSEQ™ sequencing technology, for great sequencing data at the lowest cost in the industry.
DNBSEQ™ is BGI’s proprietary sequencing technology, developed by our Complete Genomics subsidiary in Silicon Valley.
We care for your samples from the start through to the result reporting. Highly experienced laboratory professionals follow strict quality procedures to ensure the integrity of your results.
We care for your samples from the start through to the result reporting. Highly experienced laboratory professionals follow strict quality procedures to ensure the integrity of your results.
Send us a no obligation request for quote and our dedicated sales team will reply to you within 24 hours.
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BGI Human Genome Sequencing Services are performed with BGI’s DNBSEQ™ sequencing technology, featuring DNA Nanoballs, linear Rolling Circle Replication and cPAS technology for superior data quality.
We can process your gDNA, saliva, blood, fresh frozen tissue, cell pellets and FFPE samples, with the following general requirements:
Regular Samples
Intact genomic DNA ≥ 1μg, Concentration ≥ 12.5ng/ μl
15 μl
PCR-free Samples
Intact genomic DNA ≥ 2μg, Concentration ≥ 12.5ng/ μl
15 μl
Low Input Samples
Intact genomic DNA ≥ 200ng, Concentration ≥ 2.5 ng/ μl
15 μl
In addition to raw data output, BGI offers a range of standard and customized bioinformatics pipelines for your Low-Pass whole genome sequencing project.
Read alignment
Variant calling by imputation (reference panel: 1000 Genomes Phase 3)
Ancestry inference
Microbiome profiling
Further customization of Bioinformatics analysis to suit your unique project is available:
Please contact your BGI technical representative.
Read or download Low-Pass Whole Genome Sequencing documentation and data. Don't find what you need right away? Please contact your local BGI representative.
