The combination of linear amplification and DNB technology reduces the error rate while enhancing the signal. The size of the DNB is controlled in such a way that only one DNB is bound per active site on the flow cell. This densely patterned array technology provides optimal sequencing accuracy and increases flow cell utilization.
Our DNBseq™ Small RNA sequencing service with optional UMI technology delivers accurate, affordable and high-quality sequencing data to support your academic and clinical research applications.
To demonstrate the high technical reproducibility of the DNBseq™ technology platform for small RNA sequencing, six human brain samples, two heart samples and two blood samples were sequenced . Reproducibility was assessed by using six technical replicates of human brain sample. The median correlation between the six replicates was 0.98, and the 25% and 75% quantile were 0.98 and 0.99, respectively.
Read the Data in our Service Overview
 Fu Y, Wu PH, Beane T, Zamore PD, Weng Z: Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers. BMC Genomics 2018;19:531.
 Drmanac R et al. : Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science 2010;327:78-81.
 Fehlmann T, Reinheimer S, Geng C, Su X, Drmanac S, Alexeev A, Zhang C, Backes C, Ludwig N, Hart M, An D, Zhu Z, Xu C, Chen A, Ni M, Liu J, Li Y, Poulter M, Li Y, Stahler C, Drmanac R, Xu X, Meese E, Keller A: cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs. Clin Epigenetics 2016;8:123.