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02/05/2019

1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses



Researchers from BGI-Shenzhen, the South China University of Technology, and elsewhere have isolated almost 6,500 bacterial representatives from fecal samples donated by 155 healthy individuals, using 11 types of growth media to culture the gut bacteria under anaerobic conditions in the lab.

From there, the investigators turned to 16S ribosomal RNA sequencing, as well as whole-genome sequencing for almost 1,800 isolates, to produce 1,520 high-quality draft genomes for bacteria from 388 species clusters spread across the bacterial phylogenetic tree, including 264 new reference genomes in 134 species clusters.

The strains are now part of the China National GeneBank and may be useful for studies that aim to alter microbiota functions, as novel probiotics, or for verification of disease-associated bacterial markers.

Learn more about our commercial services for 16S sequencing or bacteria WGS services.

Or read the study.

 

BGI Nature Biotech Study
1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses

 

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