Proven DNBseq sequencing technology combines the power of DNA Nanoballs (DNB™), PCR-free Rolling Circle Replication, Patterned Nano Arrays and cPAS to deliver a new level of data clarity and affordability.
The combination of linear amplification and DNB technology reduces the error rate while enhancing the signal, resulting in real advantages.
NGS data from DNBseq technology is well documented with over 800 peer-reviewed publications and is exclusively available from BGI.
DNA NanoBalls (DNBs)
Small, very high-density sequencing templates…
Rolling-Circle Replication (RCR)
Linear Amplification makes only copies of the original DNA template instead of copy-of-a-copy
Patterned Nano Array
Billions of spots are compacted on a high-density patterned nanoarray.
Combinatorial Probe-Anchor Synthesis
Sequencing chemistry optimized for DNBseq
Smaller DNB spots with highly concentrated DNA delivers 7.5x higher dye density than PCR cluster arrays, leading to higher Signal-to-Noise for optimal imaging signal integrity.
Fewer Sequencing Errors
RCR does not amplify errors: 1 error in 1Mb of called bases in SE150
Higher Sensitivity and Accuracy
Supports low frequency mutation detection such as ctDNA early cancer detection
No Sample Index Mis-assignment
Safely pool samples without loss of data integrity
Lower Sequencing Cost
Make your research budget go further