For research use only. Not for use in diagnostic procedures.

Microbiological Research

Microbial research relates to all aspects of human life. BGI has initiated or participated in 10K microbial genome project, Metagenomics of the Human Intestinal Tract (MetaHIT), 1 million microbial ecological genome projects, and Earth Microbiome Project (EMP) etc., utilizing various next-gene sequencing methods.

PMseq^TM high-throughput genetic detection of pathogenic microorganisms 

PMseq^TM (Pathogen Metagenomics Sequencing) is direct high-throughput sequencing of infected specimens, through microbial-specific database comparison and intelligent algorithm analysis, obtaining species information of suspected pathogenic microorganisms, and providing comprehensive and in-depth reports for rapid and accurate detection of difficult- and critical-to-detect infections, and promoting the rational use of antibiotics under Antibiotic Stewardship Programs (ASP) with insights of antimicrobial resistance and susceptibility (AMR).

Based on metagenomics technology, all nucleic acids from infected specimens are extracted and subjected to different sample pretreatments, and then sequenced. Through the leading-edge, polished, high-quality pathogen metagenomics database (PMDB) comparison and intelligent proprietary automated bioinformatics algorithm analysis (PMseq Datician^TM), the suspected pathogenic species list and report can be obtained. Species information of microorganisms, unbiased detection of 17,500+ pathogens such as bacteria, fungi, viruses, parasites, etc., significantly improves the positive rate of pathogen detection by our clients. 

We enable customer's end-to-end syndromic or pan-syndromic testing of microbials' DNA, RNA, DNA+RNA from various sample types with the following proven products/platforms (RUO in US and Canada).

*MGISP-100 and DNBSEQ-G400 are supplied by Complete Genomics directly.

PMseq™ introduction video: 

Advantages of PMseq™ solutions

Highlighted Publications: 

[1] Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding
Journal: The Lancet
Issuing Time: January, 2020
DOI:10.1016/ S0140-6736(20)30251-8

[2] Metagenomic next-generation sequencing technology for detection of pathogens in blood of critically ill patients.
Journal: International Journal of Infectious Diseases
Issuing Time: February, 2021
DOI:10.1016/j.ijid.2020.11.166

[3] Aetiology of Severe Community Acquired Pneumonia in Adults Identified by Combined Detection Methods: A Multi-center Prospective Study in China
Journal: Emerging Microbes & Infections
Issuing Time: January, 2022
DOI:10.1080/22221751.2022.2035194

Webinars:

 [1] Title: Point-of-Care and Metagenomic Infectious Disease Testing at Hospitals in Shanghai and Beijing

Duration: 1 hour, 5 minutes
Register and Watch the Webinar Now!

 [2] Title: Application of Metagenomic NGS in Immunodeficient Patients

Duration: 1 hour
Register and Watch the Webinar Now!

Download PMSeq Flyer

Contact us for early access！