Publications

BGI has generated over 2097 publications in top-tier journals, such as Nature and Science. *All links lead to external websites.

2017

Metagenomics

Microorganism

seeksv: an accurate tool for somatic structural variation and virus integration detection Link

2016

Metagenomics

Microorganism

A reference gene catalogue of the pig gut microbiome Link

2015

Plant & Animal Resequencing

Animal

Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequencing Link

2015

Epigenomics

BS-SNPer: SNP calling in Bisulfite-seq data Link

2015

RNA-seq(Q)

Human

Comparison of six different pretreatment methods for blood RNA extraction Link

2009

Plant & Animal Resequencing

Animal

Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx) Link

2012

RNA-seq(Q)

Human

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome Link

2016

Metagenomics

Microorganism

First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection Link

2015

RNA-seq(Q)

Human

Full-length single-cell RNA-seq applied to a viral human cancer: applications to HPV expression and splicing analysis in HeLa S3 cells Link

2010

Plant & Animal Resequencing

Plant

Genome-wide patterns of genetic variation among elite maize inbred lines Link

2012

Small RNA

Plant

Identification of Soybean MicroRNAs Involved in Soybean Cyst Nematode Infection by Deep Sequencing Link

2008

Epigenomics

Human

MethyCancer: the database of human DNA methylation and cancer Link

2015

Metagenomics

Microorganism

Mutational bias of Turnip Yellow Mosaic Virus in the context of host anti-viral gene silencing Link

2012

Plant & Animal Resequencing

Plant

Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes Link

2010

Plant & Animal Resequencing

Plant

Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection Link

2016

RNA-seq(Q)

Human

RNA-Seq Reveals the Angiogenesis Diversity between the Fetal and Adults Bone Mesenchyme Stem Cell Link

2010

Small RNA

Sequencing bias: comparison of different protocols of microRNA library construction Link

2016

Metagenomics

Microorganism

Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome Link

2010

Epigenomics

Animal

Single base-resolution methylome of the silkworm reveals a sparse epigenomic map Link

2016

RNA-seq(Q)

Human

Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis Link

2013

RNA-seq(Q)

Human

SOAPfuse: an algorithm for identifying fusion transcripts from paired-end RNA-Seq data Link

2017

RNA-seq(Q)

Human

Single-cell RNA-seq reveals lincRNA expression differences in Hela-S3 cells Link

2013

Epigenomics

Human

Sorafenib Inhibits Epithelial-Mesenchymal Transition through an Epigenetic-Based Mechanism in Human Lung Epithelial Cells Link

2017

Small RNA

Plant

Transcriptome-Wide Identification and Prediction of miRNAs and Their Targets in Paris polyphylla var. yunnanensis by High-Throughput Sequencing Analysis Link

2010

Epigenomics

Human

Whole genome DNA Methylation analysis based on high throughput sequencing technology Link

2013

Plant & Animal Resequencing

Animal

Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation Link

2013

De Novo Genome Sequencing

Plant

Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation Link

2012

De Novo Genome Sequencing

Animal

Analyses of pig genomes provide insight into porcine demography and evolution Link

2016

Metagenomics

Microorganism

Detection of Listeria monocytogenes in CSF from Three Patients with Meningoencephalitis by Next-Generation Sequencing Link

2013

De Novo Genome Sequencing

Plant

Draft genome of the wheat A-genome progenitor Triticum urartu Link

2013

De Novo Genome Sequencing

Plant

Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement Link

2016

Metagenomics

Microorganism

Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice Link

2015

De Novo Genome Sequencing

Plant

Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution Link

2013

De Novo Genome Sequencing

Animal

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome Link

2014

Metagenomics

Microorganism

Influenza H7N9 and H9N2 Viruses: Coexistence in Poultry Linked to Human H7N9 Infection and Genome Characteristics Link

2016

Metagenomics

Microorganism

Metagenome-wide association studies: fine-mining the microbiome Link

2013

De Novo Genome Sequencing

Animal

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse Link

2012

Metagenomics

Microorganism

Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation Link

2012

De Novo Genome Sequencing

Animal

The oyster genome reveals stress adaptation and complexity of shell formation Link

2016

De Novo Genome Sequencing

Animal

The seahorse genome and the evolution of its specialized morphology Link

2012

De Novo Genome Sequencing

Plant

The tomato genome sequence provides insights into fleshy fruit evolution Link

2018

Exome

Human

C/EBP β enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation link

2014

Exome

Human

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
link

2014

Exome

Human

Human intracellular ISG15 prevents interferon-α/βover-amplification and auto-inflammation.
link

2015

Exome

Human

The UK10K project identifies rare variants in health and disease
link

2014

Exome

Human

Identification of genomic alterations in oesophageal squamous cell cancer
link

2014

Exome

Human

Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing's Syndrome
link

2013

Exome

Human

A large-scale screen for coding variants predisposing to psoriasis
link

2016

Exome

Human

Genomic heterogeneity of multiple synchronous lung cancer
link

2016

Exome

Human

Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population
link

2018

Metagenomics

BGISEQ-500

Animal

A gene catalogue of the Sprague-Dawley rat gut metagenome

2018

BGISEQ-500

Plant

A guide to sequence your favorite plant genomes

2018

Metagenomics

BGISEQ-500

Human

A novel affordable reagent for room temperature storage and transport of fecal samples for metagenomic analyses

2018

RNA-Seq

BGISEQ-500

Plant

A novel HD-ZIP IV/MIXTA complex promotes glandular trichome initiation and cuticle development in Artemisia annua

2018

Exome

BGISEQ-500

Human

A novel mutation in PRPF31, causative of autosomal dominant retinitis pigmentosa, using the BGISEQ-500 sequencer

2018

Exome

BGISEQ-500

Human

A novel PTCH1 mutation underlies non‐syndromic cleft lip and/or palate in a Han Chinese family

2017

WGS

BGISEQ-500

Human

A reference human genome dataset of the BGISEQ-500 sequencer

2018

RNA-Seq

BGISEQ-500

Animal

A small set of differentially expressed genes was associated with two color morphs in natural populations of the pea aphid Acyrthosiphon pisum

2018

RNA-Seq

BGISEQ-500

Human

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells

2018

RNA-Seq

BGISEQ-500

Human

An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation

2018

RNA-Seq

BGISEQ-500

Human

Anti‑fbrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn’s Disease

2018

RNA-Seq

BGISEQ-500

Plant

Arabidopsis thaliana ACS8 plays a crucial role in the early biosynthesis of ethylene elicited by Cu2+ ions

2017

Metagenomics

BGISEQ-500

Human

Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing

2017

RNA-Seq

BGISEQ-500

Plant

AtACS8 plays a critical role in the early biosynthesis of ethylene elicited by copper ions in Arabidopsis

2018

RNA-Seq

BGISEQ-500

Human

Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival

2018

RNA-seq & miRNA

BGISEQ-500

Human

Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy

2018

RNA-Seq

BGISEQ-500

Animal

Cambogin suppresses dextran sulphate sodium‐induced colitis by enhancing Treg cell stability and function

2017

RNA-Seq

BGISEQ-500

Animal

Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia

2018

Small RNA

BGISEQ-500

Microorganism

Comparative genome-wide analysis of extracellular small RNAs from the mucormycosis pathogen Rhizopus delemar

2017

WGS

BGISEQ-500

Animal

Comparative performance of the BGISEQ-500 versus Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing

2016

RNA-Seq

BGISEQ-500

Animal

Comparative transcriptome analysis of chemosensory genes in two sister leaf beetles provides insights into chemosensory speciation.

2018

Transcriptome de novo

BGISEQ-500

Animal

Comparative transcriptome analysis of Sogatella furcifera (Horváth) exposed to different insecticides

2018

RNA-Seq

BGISEQ-500

Plant

Comparative transcriptome analysis reveals key genes potentially related to soluble sugar and organic acid accumulation in watermelon

2018

Plastome DNA

BGISEQ-500

Plant

Complete plastome sequence of Dracaena cambodiana (Asparagaceae): a species considered “Vulnerable” in Southeast Asia

2018

RNA-Seq

BGISEQ-500

Plant

Compositional and transcriptomic analysis associated with cuticle lipid production on rosette and inflorescence stem leaves in the extremophyte Thellungiella salsuginea

2017

RNA-Seq

BGISEQ-500

Microorganism

Coordination of metabolic pathways: Enhanced carbon conservation in 1,3-propanediol production by coupling with optically pure lactate biosynthesis

2018

RNA-Seq

BGISEQ-500

Animal

Cranial Irradiation Induces Hypothalamic Injury and Late-Onset Metabolic Disturbances in Juvenile Female Rats

2016

Small RNA

BGISEQ-500

Human

cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs

2018

Small RNA

BGISEQ-500

Plant

DDM1 represses noncoding RNA expression and RNA-directed DNA methylation in heterochromatin

2018

RNA-Seq

BGISEQ-500

Microorganism

Differential gene expression in Escherichia coli during aerosolization from liquid suspension

2017

RNA-Seq

BGISEQ-500

Animal

Differential gene expression in the intestine of sea cucumber (Apostichopus japonicus) under low and high salinity conditions

2017

RNA-Seq

BGISEQ-500

Human

Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells

2017

RNA-Seq

BGISEQ-500

Plant

Draft genome sequence of the Tibetan medicinal herb, Rhodiola crenulata

2017

RNA-Seq

BGISEQ-500

Animal

Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila

2018

RNA-Seq

BGISEQ-500

Animal

Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

2017

RNA-Seq

BGISEQ-500

Human

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner

2017

RNA-Seq

BGISEQ-500

Animal

Effects of In Utero PFOS Exposure on Transcriptome, Lipidome and Function of Mouse Testis

2018

Metagenomics

BGISEQ-500

Human

Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis: protocol for a 6-month, double-blind, randomised, placebo-controlled trial

2017

RNA-Seq

BGISEQ-500

Human

Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

2017

RNA-Seq

BGISEQ-500

Animal

Exploring gene expression changes in the amphioxus gill after poly(I:C) challenge using digital expression profiling

2018

RNA-Seq

BGISEQ-500

Human

FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway

2018

RNA-Seq

BGISEQ-500

Plant

Expression of grape ACS1 in tomato decreases ethylene and alters the balance between auxin and ethylene during shoot and root formation

2017

RNA-Seq

BGISEQ-500

Human

FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt/β-catenin Signaling Pathway

2018

RNA-Seq

BGISEQ-500

Animal

Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells

2017

RNA-Seq

BGISEQ-500

Plant

Gene expression profiling of ramie roots during hydroponic induction and adaption to aquatic environment

2017

RNA-Seq

BGISEQ-500

Plant

Genome-scale mRNA transcriptomic insights into the responses of oilseed rape (Brassica napus L.) to varying boron availabilities

2017

RNA-Seq

BGISEQ-500

Animal

Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions

2018

WGS

BGISEQ-500

Human

Germline and somatic variant identification using BGISEQ-500 and HiSeq X Ten whole genome sequencing

2018

RNA-Seq

BGISEQ-500

Animal

Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression

2017

RNA-Seq

BGISEQ-500

Human

Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia

2017

RNA-Seq

BGISEQ-500

Human

High expression of diffuse panbronchiolitis critical region 1 gene promotes cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma

2018

RNA-Seq

BGISEQ-500

Plant

Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor

2018

RNA-Seq

BGISEQ-500

Microorganism

Identification and Characterization of als Genes Involved in D-Allose Metabolism in Lineage II Strain of Listeria monocytogenes

2018

Exome

BGISEQ-500

Human

Identification of a mutL‑homolog 1 mutation via whole‑exome sequencing in a Chinese family with Gardner syndrome

2017

RNA-Seq

BGISEQ-500

Microorganism

Identification of differentially expressed genes involved in spore germination of Penicillium expansum by comparative transcriptome and proteome approaches

2018

Metagenomics

BGISEQ-500

Human

Identification of pathogens in culture-negative infective endocarditis with metagenomic analysis

2018

RNA-Seq

BGISEQ-500

Microorganism

In Situ Lignin Bioconversion Promotes Complete Carbohydrate Conversion of Rice Straw by Cupriavidus basilensis B-8

2018

RNA-Seq

BGISEQ-500

Animal

KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

2018

RNA-Seq

BGISEQ-500

Human

Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery

2017

RNA-Seq

BGISEQ-500

Human

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

2017

RNA-Seq & ChIP-Seq

BGISEQ-500

Animal

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

2017

RNA-Seq

BGISEQ-500

Animal

Orally Administrated Baker’s Yeast beta-Glucan Promotes Glucose and Lipid Homeostasis in the Livers of ob/ob Mice

2018

RNA-Seq

BGISEQ-500

Human

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase

2017

RNA-Seq

BGISEQ-500

Plant

Overexpression of OsHSP18.0-CI Enhances Resistance to Bacterial Leaf Streak in Rice

2017

RNA-Seq

BGISEQ-500

Human

Overexpression of placenta specific 8 is associated with malignant progression and poor prognosis of clear cell renal cell carcinoma

2018

RNA-Seq

BGISEQ-500

Plant

Overexpression of VaWRKY14 increases drought tolerance in Arabidopsis by modulating the expression of stress-related genes

2018

RNA-Seq

BGISEQ-500

Animal

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

2017

RNA-Seq

BGISEQ-500

Human

PBRM1 restricts the basal activity of innate immune system through repressing RIG-I-like receptor signaling and is a potential prognostic biomarker for colon cancer

2018

RNA-Seq

BGISEQ-500

Plant

Phytochrome A Negatively Regulates the Shade Avoidance Response by Increasing Auxin/Indole Acidic Acid Protein Stability

2018

RNA-Seq

BGISEQ-500

Animal

Preinduction with bone morphogenetic protein-2 enhances cardiomyogenic differentiation of c-kit+ mesenchymal stem cells and repair of infarcted myocardium

2017

RNA-Seq

BGISEQ-500

Human

Probing impaired neurogenesis in human brain organoids exposed to alcohol

2018

BGISEQ-500

Human

Quality Control of Next-generation Sequencing-based In vitro Diagnostic Test for Onco-relevant Mutations Using Multiplex Reference Materials in Plasma

2018

Yeast DNA

BGISEQ-500

Microorganism

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods

2017

RNA-Seq

BGISEQ-500

Human

Recessive mutation in EXOSC3 associates with mitochondrial dysfunction and pontocerebellar hypoplasia

2018

Methodology-index

BGISEQ-500

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

2018

RNA-Seq

BGISEQ-500

Animal

Repopulated microglia are solely derived from the proliferation of residual microglia after
acute depletion

2018

Transcriptome resequencing

BGISEQ-500

Microorganism

RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant

2018

RNA-Seq

BGISEQ-500

Human

Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing

2018

RNA-Seq

BGISEQ-500

Human

Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A
genome wide epigenetic analysis

2018

RNA-Seq

BGISEQ-500

Human

Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells

2018

Methodology-long fragment

BGISEQ-500

Single tube bead-based DNA co-barcoding for cost effective and accurate sequencing, haplotyping, and assembly

2018

RNA-seq(Q)

BGISEQ-500

Human

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

2018

RNA-Seq

BGISEQ-500

Human

Small molecules capable of activating DNA methylation–repressed genes targeted by the p38 mitogen-activated protein kinase pathway

2018

RNA-Seq

BGISEQ-500

Human

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

2017

RNA-Seq

BGISEQ-500

Animal

Systemic response of the stony coral Pocillopora damicornis against acute cadmium stress

2018

RNA-Seq

BGISEQ-500

Human

TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression

2018

Transcriptome de novo

BGISEQ-500

Plant

The biosynthetic origin of psychoactive kavalactones in kava

2018

RNA-Seq

BGISEQ-500

Microorganism

The Catabolite Repressor/Activator Cra Is a Bridge Connecting Carbon Metabolism and Host Colonization in the Plant Drought Resistance-Promoting Bacterium Pantoea alhagi LTYR-11Z

2017

Epigenomics

BGISEQ-500

Human

The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.

2018

RNA-Seq

BGISEQ-500

Plant

The GARP/MYB-related grape transcription factor AQUILO improves cold tolerance and promotes the accumulation of raffinose family oligosaccharides

2018

RNA-Seq

BGISEQ-500

Animal

The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular
Trafficking

2018

RNA-Seq

BGISEQ-500

Human

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1

2018

RNA-Seq

BGISEQ-500

Animal

The Molecular Mechanism Underlying Pro-apoptotic Role of Hemocytes Specific Transcriptional Factor Lhx9 in Crassostrea hongkongensis

2018

RNA-Seq

BGISEQ-500

Animal

Transcriptome profiling of immune-responsive genes in the intestine of Cynoglossus semilaevis Günther challenged with Shewanella algae

2018

Transcriptome de novo

BGISEQ-500

Animal

Transcriptome profiling reveals differential gene expression of detoxification enzymes in Sitophilus zeamais responding to terpinen-4-ol fumigation

2018

Transcriptome resequencing

BGISEQ-500

Plant

Transcriptome resequencing analysis of the responses of Ty5-Mediated resistance to TYLCV via in resistant vs. susceptible tomato cultivars

2017

RNA-Seq

BGISEQ-500

Plant

Transcriptome sequencing and comparative analysis of differentially-expressed isoforms in the roots of Halogeton glomeratus under salt stress

2017

Small RNA

BGISEQ-500

Animal

Transcriptome-wide analysis of immune-responsive microRNAs against poly (I:C) challenge in Branchiostoma belcheri by deep sequencing and bioinformatics

2017

RNA-Seq

BGISEQ-500

Animal

Transcriptomic analysis reveals transgenerational effect of hypoxia on the neural control of testicular functions

2017

RNA-Seq

BGISEQ-500

Animal

Using Next-Generation Sequencing to Detect Differential Expression Genes in Bradysia odoriphaga after Exposure to Insecticides

2018

RNA-Seq

BGISEQ-500

Human

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy